Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B9, also known as folate or folic acid, is scientifically validated for the support and treatment of certain types of anemia, specifically megaloblastic anemia. Calcium methylfolate is a bioavailable form of folate often used in supplementation. Folate is crucial for DNA synthesis and cell division, processes especially important in rapidly dividing cells such as those in the bone marrow where red blood cells are produced. A deficiency in folate impairs DNA synthesis, leading to the production of abnormally large and immature red blood cells (megaloblasts), resulting in megaloblastic anemia.

Numerous clinical studies and authoritative health organizations, such as the World Health Organization and the Centers for Disease Control and Prevention, recognize folate deficiency as a common cause of megaloblastic anemia, particularly in pregnant women, individuals with poor dietary intake, and those with malabsorption syndromes. Supplementation with folate, including calcium methylfolate, is the standard treatment for this type of anemia, effectively restoring normal red blood cell production when deficiency is the underlying cause.

It is important to note that folate supplementation does not treat anemia caused by other deficiencies (e.g., vitamin B12 or iron deficiency), and improper use can mask B12 deficiency, potentially leading to neurological complications. Nevertheless, the use of vitamin B9 (calcium methylfolate) for folate-deficiency anemia is well-supported by robust scientific evidence.

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