Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Sodium ascorbate, a form of vitamin C, is scientifically validated as an adjunct treatment in certain types of anemia, particularly iron-deficiency anemia. The primary mechanism involves vitamin C’s well-established ability to enhance non-heme iron absorption in the gastrointestinal tract. Non-heme iron, found in plant-based foods and supplements, is less readily absorbed compared to heme iron from animal sources. Vitamin C reduces ferric iron (Fe³⁺) to the more absorbable ferrous form (Fe²⁺) and forms soluble complexes that facilitate uptake in the intestines. Numerous clinical studies and authoritative guidelines support the co-administration of vitamin C with oral iron supplements to improve hematologic response in individuals with iron-deficiency anemia. For example, the British Society of Gastroenterology and other professional bodies recommend vitamin C as a standard adjunct to oral iron therapy, especially in populations at risk for poor absorption. However, recent randomized controlled trials suggest that while vitamin C can modestly enhance iron absorption, the overall clinical benefit may be smaller than previously thought, and not all patients require supplementation. There is limited evidence supporting sodium ascorbate specifically over other vitamin C forms, but the ascorbate ion is the active component in iron absorption. Overall, the use of sodium ascorbate or vitamin C to support iron-deficiency anemia is a practice grounded in robust scientific evidence, reflected in medical guidelines and physiological understanding.

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