Polygonatum, often referred to as Solomon's Seal, is a genus used in traditional Chinese medicine (TCM) under names such as "Huang Jing" (Polygonatum sibiricum and related species). In TCM, Polygonatum is classified as a tonic herb, traditionally used to "nourish Qi," "moisten dryness," and "tonify the spleen and lungs." It is sometimes included in herbal formulas intended to address symptoms associated with anemia, such as fatigue and weakness, by "supporting blood" or "tonifying Qi and blood." However, the direct use of Polygonatum specifically to treat or support anemia is based on traditional energetic concepts rather than modern biomedical evidence.

Scientific studies on Polygonatum focus primarily on its polysaccharide content and potential antioxidant, immunomodulatory, and anti-diabetic effects. There is little to no direct clinical or preclinical research demonstrating that Polygonatum increases hemoglobin, red blood cell count, or directly treats iron-deficiency or other forms of anemia in humans. Some animal studies suggest possible hematopoietic or adaptogenic effects, but these are preliminary and not well-established. Thus, while its use for anemia is documented in traditional herbal practice, scientific validation for this specific indication is limited or absent.