Magnesium ascorbate is a compound that combines magnesium with ascorbic acid (vitamin C). Its use in supporting or treating anemia, particularly iron-deficiency anemia, has scientific basis, primarily due to the ascorbic acid component. Vitamin C is well-established in clinical research to enhance non-heme iron absorption from the gastrointestinal tract by reducing ferric iron (Fe³⁺) to the more absorbable ferrous form (Fe²⁺) and by forming soluble iron-ascorbate complexes. Supplementation with vitamin C is often recommended to improve the efficacy of oral iron therapy, particularly in populations at risk for iron-deficiency anemia.

The magnesium component of magnesium ascorbate is not directly implicated in the treatment of anemia, although magnesium is important for general cellular function and may play indirect roles in erythropoiesis (red blood cell production). Clinical studies focus on the vitamin C aspect, with some evidence showing improved hematologic outcomes when vitamin C is co-administered with iron supplements.

However, there is limited direct research evaluating magnesium ascorbate as a unique compound for anemia compared to vitamin C alone. Thus, while the scientific rationale exists, most of the supporting evidence pertains to ascorbic acid, not magnesium ascorbate specifically. The evidence rating is moderate (3/5), reflecting well-established benefits of vitamin C for iron absorption, but lacking substantial studies specifically on magnesium ascorbate for anemia.