Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the active compound found in turmeric (Curcuma longa), has garnered attention for its use in supporting or treating anal fistula and fissure, largely due to its anti-inflammatory and wound-healing properties. Several preclinical studies and a few small-scale human clinical trials have suggested that curcumin can reduce inflammation, decrease oxidative stress, and promote tissue repair. These effects are relevant to anal fissure and fistula, conditions characterized by inflammation, pain, and impaired tissue healing.

A pilot randomized controlled study published in 2013 investigated the topical application of a turmeric-based ointment in patients with chronic anal fissure. The study found that patients using the ointment reported significant improvements in pain and healing rates compared to placebo. Additional studies, mostly from India and Iran, have reported similar benefits with curcumin or turmeric-based treatments as adjuncts to standard therapy.

The proposed mechanisms for curcumin's effects include inhibition of pro-inflammatory cytokines (such as TNF-α and IL-1β), enhancement of collagen deposition, and acceleration of epithelialization. However, the overall quality and quantity of clinical evidence remains low, with most studies being small, non-blinded, or lacking rigorous controls. There is also a traditional basis for the use of turmeric in wound healing within Ayurvedic medicine, but the current scientific validation for curcumin specifically for anal fissure or fistula is limited.

In summary, while there is some preliminary scientific evidence supporting curcumin’s adjunctive use, larger, well-designed clinical trials are needed to establish its efficacy for anal fistula and fissure treatment.

More about curcumin
More about Anal Fistula or Fissure

Other ingredients used for Anal Fistula or Fissure

Other health conditions supported by curcumin

Products containing curcumin

Nature's Sunshine Turmeric Curcumin (Formerly CurcuminBP)