Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B9, particularly in its active form as methylfolate, has some scientific rationale for its investigation in Alzheimer's Disease (AD), but the evidence remains limited and inconclusive. Folate is crucial for brain health, as it plays a role in DNA synthesis, repair, and methylation, and is involved in the metabolism of homocysteine—a compound that, at elevated levels, has been associated with cognitive decline and increased risk of AD. Some studies have shown that individuals with Alzheimer's often have lower folate levels, and higher homocysteine levels, suggesting a potential link.

Several small clinical trials and observational studies have explored whether folic acid supplementation (including methylfolate) might slow cognitive decline or improve memory in people with AD or mild cognitive impairment. Results have been mixed: some studies report modest cognitive benefits, while others show no significant effect. Larger, well-controlled randomized trials generally have not demonstrated a clear, consistent benefit of folate or methylfolate supplementation in the prevention or treatment of Alzheimer's Disease.

Current clinical guidelines do not recommend routine use of methylfolate as a treatment for Alzheimer's. The evidence is stronger for ensuring adequate folate status to prevent deficiency and possibly lower dementia risk, but not for using high-dose methylfolate as a therapy in established disease. Overall, while scientific investigation is ongoing, the evidence base remains weak (rated 2/5), and more robust research is needed to clarify any therapeutic role.

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