Evidence supporting the use of: Unsaturated fatty acid
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Unsaturated fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been investigated for their potential role in supporting or treating Alzheimer's Disease (AD). The scientific rationale is based on the role of these fatty acids in maintaining neuronal membrane fluidity, modulating inflammation, and supporting synaptic function. Epidemiological studies have observed associations between higher dietary intake of omega-3 fatty acids and a reduced risk of cognitive decline and AD. Some preclinical studies in animal models suggest that omega-3 supplementation may reduce amyloid-beta accumulation and neuroinflammation.

However, randomized controlled trials (RCTs) in human populations have yielded mixed results. Some trials have found modest benefits in slowing cognitive decline in mild cognitive impairment (MCI) or early AD, while others have shown no significant effect. Systematic reviews and meta-analyses generally conclude that the evidence for omega-3 supplementation as a treatment for established AD is weak. The American Academy of Neurology and other expert panels do not currently recommend routine omega-3 supplementation for AD prevention or treatment based on existing evidence. In summary, while there is a plausible biological basis and some epidemiological support, robust clinical evidence for the efficacy of unsaturated fatty acids in treating Alzheimer's Disease is limited, warranting a rating of 2 out of 5.

More about Unsaturated fatty acid
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acai berry
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akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
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beta caryophyllene
bifidobacterium longum
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black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
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chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
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cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
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l-serine
l-theanine
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lutein
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lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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epicatechin
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Ergothioneine
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Products containing Unsaturated fatty acid

We currently have no products on Caring Sunshine that contain this ingredient.