Evidence supporting the use of: Sulforaphane
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a naturally occurring isothiocyanate found in cruciferous vegetables like broccoli, has attracted scientific interest for its potential neuroprotective effects, including in Alzheimer's Disease (AD). The evidence base supporting its use for AD is limited to preclinical studies, with no robust clinical trials in humans to date. In animal models and in vitro studies, sulforaphane has demonstrated several mechanisms that could be beneficial in AD: activation of the Nrf2 pathway leading to increased antioxidant defenses, reduction of neuroinflammation, and enhancement of amyloid-beta clearance. For example, studies in transgenic AD mouse models have shown that sulforaphane administration can improve cognitive performance, decrease amyloid plaque burden, and reduce markers of oxidative stress. Additionally, sulforaphane has been shown to induce the expression of cytoprotective enzymes in neuronal cells and attenuate tau phosphorylation in preclinical settings.

However, translation of these findings to humans is lacking. There are currently no large-scale, peer-reviewed clinical trials demonstrating that sulforaphane supplementation improves cognitive function or slows disease progression in people with Alzheimer's Disease. The current evidence is therefore preliminary and largely preclinical, justifying a modest evidence rating. While the biological rationale and preclinical results are promising, further research—including rigorous clinical trials—is needed to establish efficacy and safety in humans.

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amino acids
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ashwagandha
astaxanthin
berberine
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Products containing Sulforaphane

We currently have no products on Caring Sunshine that contain this ingredient.