Evidence supporting the use of: Pterostilbene
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pterostilbene is a natural compound structurally similar to resveratrol, found in blueberries and other plants. Its use for Alzheimer's Disease (AD) is supported by a growing body of preclinical (animal and cell culture) research, though clinical evidence in humans is limited. Pterostilbene has demonstrated antioxidant, anti-inflammatory, and neuroprotective properties in laboratory studies. Several studies in animal models of Alzheimer's have shown that pterostilbene can reduce oxidative stress, decrease amyloid-beta accumulation (a hallmark of AD), and improve cognitive function. For example, a 2012 study in mice reported that pterostilbene improved cognitive performance and reduced markers of neurodegeneration. Mechanistic research suggests it may modulate signaling pathways related to inflammation and cell survival (e.g., SIRT1 activation). However, as of mid-2024, no large-scale, well-controlled clinical trials in humans have definitively proven its benefit for Alzheimer's patients. The existing clinical data are mostly focused on safety and pharmacokinetics, not on cognitive outcomes. As such, while there is scientific rationale and encouraging preclinical evidence for pterostilbene’s potential in Alzheimer's Disease, the overall evidence is preliminary, and its efficacy in humans remains unproven.

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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
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gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
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soy isoflavones
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Products containing Pterostilbene

We currently have no products on Caring Sunshine that contain this ingredient.