Evidence supporting the use of: Pentacyclic triterpenoids (unspecified)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pentacyclic triterpenoids are a large class of plant-derived compounds found in many medicinal herbs, including asiatic acid, ursolic acid, oleanolic acid, and betulinic acid. Their potential neuroprotective effects have prompted scientific interest in their application to neurodegenerative disorders such as Alzheimer's Disease (AD). Preclinical research, primarily in cell cultures and animal models, demonstrates that certain pentacyclic triterpenoids may exert beneficial effects relevant to AD pathology. These include antioxidant activity, inhibition of amyloid-beta aggregation, anti-inflammatory effects, and modulation of signaling pathways involved in neuronal survival and synaptic plasticity. For example, asiatic acid (from Centella asiatica) and oleanolic acid have shown the ability to reduce amyloid plaque formation and oxidative stress in rodent models.

Despite these promising mechanisms, robust clinical evidence in humans is lacking. Most studies to date are limited to in vitro or animal experiments, with only a few preliminary human trials (often as part of complex herbal mixtures rather than isolated triterpenoids). Thus, while there is a scientific rationale and some preclinical validation, the evidence base does not yet justify strong clinical recommendations for pentacyclic triterpenoids in the treatment or support of Alzheimer's Disease. Ongoing research may clarify their therapeutic potential, but as of now, the evidence is best rated as low to moderate (2 out of 5).

More about Pentacyclic triterpenoids (unspecified)
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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
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quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
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gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
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Apocynin
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bacoside
Baicalin
Caffeic Acid
Centrophenoxine
Camellia sinensis
Caryophyllene
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Crocin
Carnosine
Catalpol
Cyanidin
Curcuminoid
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Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
Cytidine
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Fo-Ti
Fish
Fatty acids
Flavanones
Flavans
Flavonones
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Gallic Acid
Ginsenosides
Garcinol
Ginkgetin
Galantamine
Gallate
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Ginkgoheteroside
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Products containing Pentacyclic triterpenoids (unspecified)

We currently have no products on Caring Sunshine that contain this ingredient.