Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Norvaline is a non-proteinogenic amino acid that has been investigated in preclinical studies for its potential neuroprotective effects, particularly in the context of Alzheimer's Disease (AD). The scientific interest in norvaline centers on its role as an arginase inhibitor, which may enhance nitric oxide (NO) production by increasing the availability of L-arginine, a substrate for nitric oxide synthase. Since impaired NO signaling and neuroinflammation are implicated in the pathogenesis of AD, norvaline's theoretical benefit is based on its potential to restore NO levels and reduce neuroinflammation.

The evidence supporting norvaline's use in Alzheimer's Disease is limited to a handful of animal studies. For example, some research in transgenic mouse models of AD has shown that norvaline supplementation can reduce amyloid-beta accumulation, decrease inflammation, and improve cognitive performance. However, these effects have not been replicated or validated in human clinical trials. There is no traditional use of norvaline for dementia or neurodegenerative disease, and it is not an established therapy in any medical guidelines.

In summary, while there is preliminary scientific evidence from animal studies suggesting a possible benefit of norvaline in Alzheimer's Disease, the evidence is weak (rated 1/5), and no robust clinical trials in humans exist. Its use for this purpose should be considered experimental and not evidence-based at this time.

More about Norvaline
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
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AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Aronia melanocarpa
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Amentoflavone
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Ampelopsin
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Creatine
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Carnosic acid
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Docosahexaenoic Acid
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epicatechin
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Estrogen
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Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Ginkgoheteroside
Glucoraphanin
Gastrodin
Ketone Salts
walnut

Other health conditions supported by Norvaline

Alzheimer's Disease

Products containing Norvaline

We currently have no products on Caring Sunshine that contain this ingredient.