Evidence supporting the use of: Nobiletin
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nobiletin is a polymethoxylated flavone found primarily in citrus peels. Its use in relation to Alzheimer's Disease (AD) is supported by preclinical scientific evidence, though no established tradition of use for this purpose exists. Several animal and in vitro studies have demonstrated that nobiletin may have neuroprotective effects relevant to Alzheimer's pathology. Mechanistically, nobiletin has been reported to improve memory impairment and cognitive function in mouse models of AD, potentially through its antioxidant and anti-inflammatory properties, inhibition of amyloid-beta aggregation, and enhancement of synaptic plasticity. For example, studies published in journals such as Neuropharmacology and Journal of Pharmacological Sciences have shown that nobiletin administration attenuates learning deficits and reduces amyloid plaque deposition in transgenic AD mice.

Additionally, nobiletin is thought to modulate pathways related to cyclic AMP (cAMP) response element-binding protein (CREB) signaling, which is important for memory formation. Despite these promising animal data, evidence in humans is lacking. There are no published clinical trials as of June 2024 that clearly demonstrate efficacy or safety in people with Alzheimer's Disease. Thus, while the scientific rationale is based on experimental models, the current level of evidence supporting nobiletin's use for AD is preliminary, and further clinical research is required before its clinical application can be recommended.

More about Nobiletin
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Other ingredients used for Alzheimer's Disease

acai berry
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akkermansia muciniphila
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alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
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chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
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quercetin
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resveratrol
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rosemary
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tocotrienols
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vitamin C
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epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
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Fish
Fatty acids
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Flavones
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Ginsenosides
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Ginkgetin
Galantamine
Gallate
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
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Products containing Nobiletin

We currently have no products on Caring Sunshine that contain this ingredient.