Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium Beta-Hydroxybutyrate (Mg BHB) is a form of exogenous ketone supplement, delivering both magnesium and beta-hydroxybutyrate (BHB), a ketone body. The rationale for its use in Alzheimer’s Disease (AD) stems from emerging scientific evidence that impaired glucose metabolism in the brain is an early feature of AD. Ketones, such as BHB, serve as an alternative energy substrate for neurons when glucose utilization is compromised. This metabolic shift is the basis for interest in ketogenic diets and exogenous ketones for neurodegenerative diseases.

Several small clinical studies and animal models have shown that increasing ketone availability (through ketogenic diets or ketone esters/salts) can modestly improve cognitive function in individuals with mild to moderate AD or mild cognitive impairment (MCI). For example, a 2018 randomized controlled trial (RCT) by Fortier et al. demonstrated that supplementation with a ketogenic medium-chain triglyceride (MCT) drink improved cognitive outcomes compared to placebo in participants with MCI. However, these studies typically use MCTs rather than BHB salts, and only a few pilot studies have directly tested exogenous BHB in AD patients. The evidence is limited to short-term trials with small sample sizes and varying formulations.

There is no robust, large-scale clinical evidence specifically for Magnesium Beta-Hydroxybutyrate in AD, and the effect size reported in existing studies is modest. Current support for its use is preliminary and based on the theoretical framework of ketone supplementation and early clinical findings. Therefore, while there is a scientific rationale and limited early evidence, more research is needed to establish efficacy and safety.

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acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
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black tea
blueberry
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butyrate triglyceride
caffeine
cannabis sativa oil
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catechins
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DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
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l-carnitine
l-carnosine
l-serine
l-theanine
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lutein
luteolin
lycopene
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marine lipid
matcha
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melatonin
n-acetyl-cysteine (NAC)
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niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
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phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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pomegranate
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vitamin D
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Crocetin
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epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
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Garcinol
Ginkgetin
Galantamine
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Ginkgo Flavone Glycoside
Ginkgoside
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Other health conditions supported by Magnesium Beta-Hydroxybutyrate

Alzheimer's Disease
Athletic and Exercise Aids
Fatigue
Migraine
Weight Loss

Products containing Magnesium Beta-Hydroxybutyrate

We currently have no products on Caring Sunshine that contain this ingredient.