Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a naturally occurring flavonoid found in many fruits, vegetables, and medicinal herbs. Its use in Alzheimer’s Disease (AD) is primarily supported by preclinical scientific studies rather than traditional medicine. Research indicates that luteolin possesses anti-inflammatory, antioxidant, and neuroprotective properties, all of which are relevant to the pathological mechanisms underlying AD. In vitro and animal studies suggest that luteolin can inhibit microglial activation, reduce the production of pro-inflammatory cytokines, and decrease amyloid-beta deposition, which are key features implicated in AD progression. For example, studies in transgenic mouse models of AD have shown that luteolin administration can improve cognitive performance and reduce neuropathological hallmarks of the disease.

However, the evidence supporting its use in humans is currently limited. There are few, if any, high-quality clinical trials evaluating the efficacy and safety of luteolin in AD patients. Most available data come from laboratory or animal studies, which do not always translate to human benefit. Therefore, while scientific interest and mechanistic justification exist for luteolin’s potential role in AD, the clinical evidence remains preliminary. More robust human studies are needed before luteolin can be recommended as a treatment or preventive agent for Alzheimer's Disease.

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