Evidence supporting the use of: Ginkgo Falvone Glycoside
For the health condition: Alzheimer's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Ginkgo flavone glycosides are the principal active compounds in standardized Ginkgo biloba extracts, which have been studied for their potential effects on cognitive decline and Alzheimer's disease. The rationale for their use is primarily scientific rather than traditional: while Ginkgo biloba has a long history in traditional medicine, its application specifically for Alzheimer's disease is relatively recent and based on modern pharmacological research.
Multiple randomized controlled trials (RCTs) and meta-analyses have investigated Ginkgo biloba extract (especially EGb 761, standardized to 24% flavone glycosides) in mild to moderate Alzheimer's disease and vascular dementia. These studies suggest that Ginkgo may have modest benefits in improving or stabilizing cognitive function, activities of daily living, and neuropsychiatric symptoms compared to placebo. Proposed mechanisms include antioxidant effects, improved cerebral blood flow, inhibition of platelet-activating factor, and modulation of neurotransmitter systems. However, the magnitude of benefit is generally small, and some large, high-quality studies (e.g., the Ginkgo Evaluation of Memory [GEM] study) did not find significant effects for preventing dementia.
Overall, systematic reviews and guidelines generally conclude that Ginkgo biloba extract may have a small but statistically significant effect on cognitive symptoms in dementia, but results are mixed and clinical relevance is debated. The evidence is not strong enough to recommend it as a first-line treatment, but it is recognized as a plausible adjunct by some practitioners. Thus, the scientific support for Ginkgo flavone glycosides in Alzheimer's is moderate but not definitive.
More about Ginkgo Falvone Glycoside
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Other ingredients used for Alzheimer's Disease
acai berryacetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Aronia melanocarpa
Anserine
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Agmatine
Acetylcholine
Amentoflavone
Acacetin
Alpha-Lipoic Acid
Astragaloside
Ampelopsin
Aniracetam
Apocynin
Black Seed
Bilobalide
Butylphthalide
Beta-hydroxybutyrate
Bacopin
Baicalein
Benfotiamine
Basidiomycota
Brahmi
Bacopa
Bifidobacteria
bacoside
Baicalin
Caffeic Acid
Centrophenoxine
Camellia sinensis
Caryophyllene
Cinnamomum
Crocin
Carnosine
Catalpol
Cyanidin
Curcuminoid
Curcumen
Chinese Ligustrum berry
Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
Cytidine
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Fo-Ti
Fish
Fatty acids
Flavanones
Flavans
Flavonones
Flavanols
Flavones
Gallic Acid
Ginsenosides
Garcinol
Ginkgetin
Galantamine
Gallate
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Ginkgoheteroside
Glucoraphanin
Gastrodin
Ketone Salts
walnut
Other health conditions supported by Ginkgo Falvone Glycoside
Alzheimer's DiseaseAnxiety
Circulation (poor)
Circulation (to the brain)
Dementia
Memory and Brain Function
Peripheral Neuropathy
Strokes
Tinnitus
