Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Gastrodia elata, commonly known as Tian Ma, is a traditional herb used in Chinese medicine primarily for neurological conditions such as headaches, dizziness, and convulsions. Its application for Alzheimer's Disease stems largely from its historical use in treating cognitive disorders and symptoms that overlap with dementia. In Chinese herbal practice, Gastrodia is believed to "calm the liver" and "extinguish wind," concepts which correspond loosely to reducing neurological agitation and spasms.

While there has been emerging interest in Gastrodia's neuroprotective effects, the bulk of its use in Alzheimer's Disease is based on traditional practices rather than robust scientific validation. Some preclinical studies, mostly in animal models, have shown that gastrodin (the major bioactive compound in Gastrodia) may exert antioxidant, anti-inflammatory, and anti-apoptotic effects in the brain. These effects theoretically could help mitigate neurodegeneration. However, human clinical evidence is either lacking or of low quality, and no major medical guidelines recommend Gastrodia for Alzheimer's Disease.

In summary, Gastrodia is traditionally used for neurological symptoms, and its application in Alzheimer's is an extension of these historical uses. Scientific studies have begun to explore its mechanisms, but current evidence supporting its efficacy for Alzheimer's in humans is limited, justifying a modest evidence rating.

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