Evidence supporting the use of: Flavonoid glycosides
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoid glycosides, particularly those found in plants like Ginkgo biloba (notably quercetin, kaempferol, and isorhamnetin glycosides), have been investigated for their potential to support or treat Alzheimer's Disease (AD). Preclinical studies indicate that flavonoid glycosides may possess neuroprotective properties, including antioxidant effects, inhibition of amyloid-beta aggregation, reduction of neuroinflammation, and modulation of signaling pathways involved in neuronal survival. Some clinical trials using Ginkgo biloba extracts (which are rich in flavonoid glycosides) have shown mild cognitive benefits in patients with mild to moderate dementia, including AD, but results are inconsistent and often modest. Systematic reviews and meta-analyses suggest there may be small improvements in cognitive function, but the evidence is not robust, with many studies suffering from methodological limitations, small sample sizes, or short durations.

As of 2024, no major clinical guidelines recommend flavonoid glycosides as a primary treatment for Alzheimer's Disease. Their use is best considered as adjunctive and experimental. Further, the observed effects in clinical trials may be attributable to multiple components of the extracts, not just the flavonoid glycosides themselves. In summary, while there is some scientific support for the neuroprotective actions of flavonoid glycosides in laboratory models and limited clinical evidence suggesting minor cognitive benefits, the overall quality and consistency of evidence is low, justifying a moderate-low rating.

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Products containing Flavonoid glycosides

We currently have no products on Caring Sunshine that contain this ingredient.