Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fisetin is a naturally occurring flavonoid found in various fruits and vegetables, such as strawberries, apples, and onions. Scientific interest in fisetin as a potential therapeutic agent for Alzheimer’s Disease (AD) has grown in recent years, but it is not a traditional remedy for dementia. Preclinical studies in cell cultures and animal models have demonstrated that fisetin exhibits multiple neuroprotective actions relevant to AD, including anti-inflammatory, antioxidant, and anti-amyloid properties. For example, fisetin has been shown to reduce amyloid-beta aggregation, decrease tau phosphorylation, and mitigate oxidative stress in transgenic mouse models of AD (Currais et al., 2014). Additionally, fisetin may enhance synaptic function and promote neuronal survival by modulating signaling pathways implicated in cognitive impairment.

Despite these promising findings in preclinical research, clinical evidence in humans remains extremely limited. As of mid-2024, there are no large, well-controlled clinical trials demonstrating that fisetin can prevent, slow, or treat Alzheimer’s Disease in humans. Some early-phase trials are underway to assess safety and possible cognitive benefits, but results are not yet available. Therefore, while there is a scientific rationale and encouraging animal data supporting the potential of fisetin for AD, its use for this condition in humans cannot yet be considered evidence-based. Further high-quality clinical trials are needed to determine its efficacy and safety in people with Alzheimer’s Disease.

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