Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 fatty acid found abundantly in the brain and is essential for normal neuronal function. Its use in supporting or treating Alzheimer’s Disease (AD) is based on scientific rationale and some clinical investigation, but the overall evidence is limited and mixed, justifying a modest evidence rating.

Epidemiological studies have observed that populations with higher dietary intake of omega-3 fatty acids, including DHA, tend to have lower rates of cognitive decline and dementia. Preclinical research in animal models and cell cultures suggests that DHA can reduce amyloid-beta accumulation, decrease neuroinflammation, and support synaptic plasticity—all processes implicated in AD pathogenesis.

However, clinical trials in humans have produced inconsistent results. Some randomized controlled trials show that DHA supplementation may modestly slow cognitive decline in individuals with mild cognitive impairment (MCI) or in early stages of Alzheimer’s, especially among those with low baseline omega-3 status or without the APOE ε4 allele. Other trials, particularly in patients with moderate to severe AD, have failed to demonstrate significant cognitive benefits.

Systematic reviews and meta-analyses generally conclude that while DHA is important for brain health, its supplementation provides limited or no significant benefit in established Alzheimer’s Disease. The evidence is stronger for a potential preventive role rather than a therapeutic one. Thus, while there is some scientific basis for DHA’s use in AD, more research is needed to clarify its effectiveness and identify which patients may benefit most.

More about DHA (docosahexaeonic acid)
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Nature's Sunshine Circulatory System
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Super Trio