Evidence supporting the use of: DHA-conjugated phosphatidylserine
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA-conjugated phosphatidylserine (DHA-PS) is used to support or potentially treat Alzheimer's Disease based on scientific rationale and emerging preclinical and clinical research, rather than tradition. Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain and is vital for neuronal membrane integrity and function. DHA (docosahexaenoic acid) is an omega-3 fatty acid crucial for brain health, and its conjugation with PS is thought to enhance delivery and efficacy. Several animal studies suggest that DHA-PS may improve cognitive function, synaptic plasticity, and reduce markers of neurodegeneration and inflammation relevant to Alzheimer’s pathology (e.g., Zhang et al., 2015, J Nutr Biochem). Small human studies with PS (often derived from bovine cortex or soy, not always DHA-conjugated) have shown modest benefits in memory and cognition in elderly populations with mild cognitive impairment, but evidence in established Alzheimer’s Disease is limited and not definitive. There is even less direct clinical data on DHA-PS specifically, with only a few pilot trials and mechanistic studies to date. Thus, while the theoretical rationale is strong and there is some scientific validation, especially in preclinical models, robust clinical evidence in Alzheimer’s Disease patients is lacking. Larger, well-controlled human trials are needed before DHA-PS can be considered an evidence-based intervention for Alzheimer’s Disease.

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Products containing DHA-conjugated phosphatidylserine

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