Evidence supporting the use of: Crocetin
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Crocetin is a natural carotenoid compound found in the crocus flower (Crocus sativus, the source of saffron) and has been investigated in recent years for its potential neuroprotective effects, including in the context of Alzheimer’s disease (AD). Preclinical studies suggest that crocetin may exert beneficial effects via several mechanisms relevant to AD pathology. These include antioxidant activity, inhibition of amyloid-beta aggregation, reduction of neuroinflammation, and mitigation of neuronal apoptosis. For example, studies in cell and animal models have shown that crocetin can reduce oxidative stress and inhibit the formation of amyloid-beta plaques, which are central features of Alzheimer’s pathology. Additionally, crocetin has been observed to modulate pathways involved in inflammation and cellular survival. However, the evidence base for crocetin's use in Alzheimer’s disease is limited primarily to in vitro (cell culture) and animal studies. There is a lack of robust clinical trials in humans evaluating its efficacy or safety for this condition. A small number of pilot human studies or reviews may mention crocetin’s potential, but the data are preliminary and insufficient for firm conclusions. Therefore, while there is some scientific rationale and early-stage evidence supporting the exploration of crocetin for Alzheimer’s disease, the overall level of evidence remains low, and its use cannot be recommended as a validated treatment at this time.

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Products containing Crocetin

We currently have no products on Caring Sunshine that contain this ingredient.