Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Catalpol and Alzheimer's Disease: Evidence Synopsis

Catalpol is an iridoid glycoside primarily isolated from Rehmannia glutinosa, a traditional Chinese medicinal herb. Over the past decade, catalpol has attracted interest for its neuroprotective properties, particularly in the context of Alzheimer's disease (AD). Preclinical studies, mainly in cell cultures and animal models, suggest that catalpol may exert beneficial effects by reducing amyloid-beta accumulation, attenuating neuroinflammation, enhancing synaptic plasticity, and protecting neurons against oxidative stress and apoptosis. Some studies have demonstrated that catalpol administration can improve cognitive performance in rodents with AD-like pathology.

The proposed mechanisms of action include upregulation of neurotrophic factors, inhibition of inflammatory cytokine release, and modulation of signaling pathways such as PI3K/Akt and Nrf2/ARE. However, no high-quality human clinical trials have been published to date, and most evidence comes from laboratory research. As such, while there is a scientific rationale and promising preclinical data supporting catalpol's potential in AD, the overall level of evidence remains low due to the absence of robust clinical validation. Further research, particularly human studies, is necessary before catalpol can be recommended for Alzheimer's disease.

More about Catalpol
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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Aronia melanocarpa
Anserine
Avocado
Agmatine
Acetylcholine
Amentoflavone
Acacetin
Alpha-Lipoic Acid
Astragaloside
Ampelopsin
Aniracetam
Apocynin
Black Seed
Bilobalide
Butylphthalide
Beta-hydroxybutyrate
Bacopin
Baicalein
Benfotiamine
Basidiomycota
Brahmi
Bacopa
Bifidobacteria
bacoside
Baicalin
Caffeic Acid
Centrophenoxine
Camellia sinensis
Caryophyllene
Cinnamomum
Crocin
Carnosine
Catalpol
Cyanidin
Curcuminoid
Curcumen
Chinese Ligustrum berry
Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
Cytidine
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Fo-Ti
Fish
Fatty acids
Flavanones
Flavans
Flavonones
Flavanols
Flavones
Gallic Acid
Ginsenosides
Garcinol
Ginkgetin
Galantamine
Gallate
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Ginkgoheteroside
Glucoraphanin
Gastrodin
Ketone Salts
walnut

Other health conditions supported by Catalpol

Alzheimer's Disease
Depression
Diabetes
Fatigue
Hypertension
Inflammation
Memory and Brain Function
Parkinson's Disease
Ulcers

Products containing Catalpol

We currently have no products on Caring Sunshine that contain this ingredient.