Evidence supporting the use of: Bacopasaponin (unspecified)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacopasaponins are a class of saponins found in Bacopa monnieri (commonly known as Brahmi), a plant used in traditional Ayurvedic medicine for cognitive enhancement. While Bacopa monnieri has a long history of traditional use for improving memory and intellect, scientific interest has centered on its possible neuroprotective and cognitive benefits, including in Alzheimer's Disease (AD).

Several preclinical studies suggest that bacopasaponins may have mechanisms relevant to AD. These include antioxidant effects, inhibition of beta-amyloid aggregation, neuroprotection, and modulation of cholinergic function. For example, animal studies have shown that Bacopa extracts and isolated bacopasaponins can reduce beta-amyloid-induced neurotoxicity and improve cognitive function in rodent models of Alzheimer's disease.

However, direct clinical evidence in humans specifically for Alzheimer's Disease is limited. Some small-scale human trials of Bacopa monnieri extract suggest modest cognitive benefits in elderly subjects and those with mild cognitive impairment, but these studies typically use whole plant extracts rather than isolated bacopasaponins, and rarely enroll subjects with clinically diagnosed AD. Systematic reviews and meta-analyses generally conclude that while Bacopa is promising for general cognitive enhancement, high-quality evidence for its efficacy in Alzheimer's Disease is lacking.

In summary, while there is mechanistic and preclinical support for bacopasaponins in the context of Alzheimer's disease, rigorous clinical trials are needed. The current evidence level is low to moderate (2/5), and recommendations are preliminary.

More about Bacopasaponin (unspecified)
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
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gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
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cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
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7,8-Dihydroxyflavone
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Baicalein
Benfotiamine
Basidiomycota
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Bacopa
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bacoside
Baicalin
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Camellia sinensis
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Crocin
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Galantamine
Gallate
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Ginkgoheteroside
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Products containing Bacopasaponin (unspecified)

We currently have no products on Caring Sunshine that contain this ingredient.