Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus species, a group of probiotic bacteria commonly found in the human gut and in fermented foods, have been studied for their potential role in modulating immune responses, including those involved in respiratory allergies such as allergic rhinitis and asthma. Several randomized controlled trials and meta-analyses have evaluated the effects of Lactobacillus supplementation on allergy symptoms. Some studies suggest that certain strains, such as Lactobacillus rhamnosus GG and Lactobacillus paracasei, may reduce the severity or frequency of symptoms related to allergic rhinitis, possibly by influencing the balance of Th1/Th2 immune responses and enhancing regulatory T cell activity. However, the evidence is inconsistent and often strain-specific, with some studies showing no significant benefit. Systematic reviews (e.g., from the Cochrane Collaboration and other groups) conclude that while there is modest evidence for a potential benefit, the overall quality of evidence is low to moderate, and effects are generally small and not always clinically meaningful. The use of unspecified Lactobacillus species for respiratory allergies is therefore based on some scientific rationale and preliminary evidence, but more well-designed, large-scale studies are needed to establish efficacy and determine which strains are most effective. At present, Lactobacillus probiotics may be considered as an adjunct but not a primary therapy for respiratory allergies.

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