Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Bioflavonoids, also known as flavonoids, are polyphenolic plant compounds found in fruits, vegetables, and certain supplements. Their use in supporting or treating respiratory allergies, such as hay fever (allergic rhinitis), is primarily based on traditional and historical use rather than robust scientific validation. In traditional medicine, particularly in Eastern and European herbal practices, bioflavonoids like quercetin and rutin have been employed for their reputed anti-inflammatory and antihistamine properties, which are thought to help alleviate symptoms of allergies such as nasal congestion, sneezing, and watery eyes. The rationale stems from observations that bioflavonoids can stabilize mast cells, potentially reducing the release of histamine—a key mediator in allergic responses. However, while some preliminary laboratory and animal studies suggest that certain bioflavonoids have anti-allergic and anti-inflammatory effects, human clinical evidence remains limited and inconsistent. Most clinical trials are small, lack rigorous controls, or use mixed bioflavonoid preparations, making it difficult to draw firm conclusions about efficacy. No major clinical guidelines recommend bioflavonoids as a primary or adjunct treatment for respiratory allergies. Therefore, while traditional use persists and some individuals report benefit, the scientific evidence supporting their use for this condition is weak, warranting a low evidence rating.

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