Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus paracasei is a probiotic bacterium that has been investigated for its potential to modulate immune responses and support the management of food allergies. The rationale for its use is primarily based on scientific research rather than traditional medicinal practices. Several preclinical studies and a handful of clinical trials have explored the effects of L. paracasei on allergic reactions, particularly those involving food allergens. These studies suggest that L. paracasei may help restore the balance of gut microbiota, promote the development of regulatory T cells, and enhance the integrity of the intestinal barrier—mechanisms that could theoretically reduce allergic sensitization and reaction severity.

For example, animal studies have shown that L. paracasei supplementation can reduce IgE production and inflammatory cytokine responses upon exposure to allergens. Some small-scale human studies and pilot clinical trials have reported improvements in symptoms of atopic dermatitis and allergic rhinitis, which are related to allergic responses, when supplemented with L. paracasei. However, robust evidence specifically targeting food allergy prevention or treatment in humans is limited, with only preliminary trials suggesting potential benefits. The probiotic is sometimes included in multi-strain formulations used in allergy research.

In summary, while there is a scientific rationale and early research supporting the use of L. paracasei for modulating allergic responses, especially in food allergies, the overall quality and quantity of clinical evidence are still modest. More large, well-controlled human trials are needed before firm conclusions can be drawn.

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