Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium (mixed species) has been investigated for its potential to modulate immune responses and improve symptoms related to food allergies, especially in early childhood. Scientific interest stems from the role of gut microbiota in the development and regulation of the immune system, with several studies indicating that individuals with allergies often have altered gut microbiota profiles, including lower Bifidobacterium abundance.

Some clinical trials, particularly in infants and young children with cow’s milk protein allergy, have shown that supplementation with mixed Bifidobacterium strains (often as part of multi-strain probiotics) may reduce allergic symptoms and promote tolerance. For example, studies have reported improved clinical outcomes and immunological markers (such as increased regulatory T cells and reduced IgE levels) in children receiving Bifidobacterium-containing formulas. However, results are inconsistent, and not all studies show a benefit.

The evidence in adults is more limited and less conclusive. Mechanistically, Bifidobacterium may enhance gut barrier function, modulate immune responses, and alter the composition of gut microbiota in ways that could be beneficial for allergy sufferers.

Overall, while there is emerging scientific evidence suggesting a potential benefit of Bifidobacterium (mixed) in managing food allergies, especially in children, the quality and consistency of evidence is moderate at best. Larger, well-designed trials are needed to confirm efficacy and to define optimal strains, dosages, and patient populations.

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