Pyridoxine (Vitamin B6) is scientifically used in the management of alcoholism, primarily due to the increased risk of vitamin B6 deficiency in individuals with chronic alcohol use. Alcohol interferes with the absorption, metabolism, and storage of several B vitamins, including B6. Deficiency of vitamin B6 in alcoholics may contribute to neurological symptoms such as peripheral neuropathy, cognitive impairment, and seizures. Clinical guidelines and medical literature recognize that supplementation with vitamin B6 is indicated in alcohol-dependent individuals, particularly those with signs of deficiency or those at risk (e.g., individuals with poor nutrition, liver disease, or malabsorption syndromes).

While B6 supplementation is not a treatment for alcoholism itself, it is an important adjunct in the management of complications arising from alcohol dependence. Evidence supports that correcting B6 deficiency can improve neurological symptoms and prevent further complications. Some protocols for treating alcohol withdrawal and Wernicke-Korsakoff syndrome (more commonly associated with thiamine deficiency) may also include B6 as part of broader B vitamin supplementation. However, robust randomized controlled trials specifically targeting B6 supplementation for alcoholism outcomes are limited; most recommendations are based on observational studies and clinical experience regarding deficiency correction rather than direct effects on alcohol dependence or withdrawal.

In summary, the use of pyridoxine in alcoholism is scientifically justified for addressing and preventing deficiency-related complications, but not for treating the addiction itself.