Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-Glutathione is a tripeptide antioxidant found naturally in the body, playing a crucial role in detoxification processes, including the metabolism of alcohol. Its use in supporting or treating alcoholism is primarily based on scientific rationale rather than tradition. Chronic alcohol consumption depletes glutathione reserves in the liver, increasing oxidative stress and contributing to liver damage. Several animal studies and some small human studies suggest that glutathione or its precursors (like N-acetylcysteine) may help mitigate alcohol-induced liver injury by replenishing intracellular glutathione levels and reducing oxidative damage.

However, direct clinical evidence supporting oral or intravenous L-glutathione supplementation for treating alcoholism itself (as opposed to managing alcohol-induced liver damage) is limited. Most studies focus on glutathione's protective effects on the liver, not on decreasing alcohol consumption or treating alcohol dependence.

In summary, while the scientific rationale exists for using L-glutathione to support liver health in the context of alcoholism, robust clinical trials confirming its effectiveness for treating alcoholism are lacking. The evidence primarily supports its adjunctive use for liver protection rather than as a primary therapy for alcohol dependence. Thus, the evidence rating is modest.

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