Evidence supporting the use of: Vitamin E (delta-tocopherol)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Delta-tocopherol is one of the lesser-known isomers of vitamin E, a group of fat-soluble antioxidants. Vitamin E as a whole has been extensively studied for its antioxidant properties, which can theoretically help mitigate oxidative stress—a key factor in cellular aging. Most research and supplementation, however, focus on alpha-tocopherol, the primary and most bioactive form of vitamin E in humans. Delta-tocopherol, along with gamma-tocopherol, has shown some antioxidant and anti-inflammatory effects in vitro and in animal models, and may help protect cells from damage caused by free radicals.

Despite these properties, there is limited direct evidence in humans that delta-tocopherol supplementation specifically slows or prevents aging. Some mechanistic studies suggest that vitamin E, including delta-tocopherol, can reduce markers of oxidative stress that are implicated in the aging process. However, large-scale clinical trials on vitamin E (mainly alpha-tocopherol) have yielded mixed results regarding aging and age-related diseases, and very few studies isolate delta-tocopherol as the active compound. Thus, while the use of vitamin E for aging prevention is supported by biological plausibility and some preliminary research, the specific role of delta-tocopherol and the overall clinical benefit remain inconclusive. The evidence supporting delta-tocopherol use for aging prevention is therefore weak to moderate, meriting a rating of 2 out of 5.

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