Evidence supporting the use of: Vitamin E
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E is an antioxidant, and its use in aging prevention is primarily supported by scientific rationale, though the strength of the evidence is moderate to low. The interest in vitamin E for aging comes from its role as a fat-soluble antioxidant, capable of neutralizing free radicals that contribute to oxidative stress—a key factor implicated in the aging process and age-related diseases. Laboratory and animal studies have shown that vitamin E can protect cell membranes from oxidative damage, theoretically slowing cellular aging. However, human studies are less conclusive. Several large-scale clinical trials and meta-analyses have found that vitamin E supplementation does not significantly reduce the risk of age-related diseases such as cardiovascular disease, cancer, or cognitive decline in the general population. In some cases, high-dose vitamin E supplementation has even been linked to increased mortality.

Despite the lack of strong evidence for disease prevention or lifespan extension, vitamin E continues to be marketed and used as an "anti-aging" supplement due to its biochemical properties and early promising research. It is also commonly included in skincare products, where it may provide some benefit in protecting skin from oxidative damage caused by UV exposure. However, experts generally recommend obtaining vitamin E from a balanced diet rather than supplements, unless there is a specific deficiency. In summary, while there is a scientific rationale for vitamin E in aging prevention, robust clinical evidence for its effectiveness in humans is lacking.

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More about Aging (prevention)

Other ingredients used for Aging (prevention)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7-hydroxymatairesinol (HMR)
7-Keto-DHEA
8-Prenylnaringenin
Abalone
Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
Algae
algal oil
Algal protein
Allantoin
Almond fruit
Alpha hydroxy acids
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anemarrhena asphodeloides
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
Antrodia camphorata
apigenin
apple
apricot
argan nut oil
Aronia melanocarpa
ascorbyl palmitate
ashitaba
ashwagandha
astaxanthin
astragaloside
astragalus
avocado
beta-carotene
bioflavonoids
bird\'s nest
Brassica
Brussel sprouts
Carnosine
carotene (unspecified)
carrot
catalase
cauliflower
Chinese Ligustrum berry
cistanche
coenzyme Q10 (CoQ10)
collagen
cruciferous
cryptoxanthin
curcumin
Curcuminoid
cycloastragenol
DHEA
DHEA (dehydroepiandrosterone)
dismutase
dodder
Dunaliella
Dunaliella salina
ellagic acid
epicatechin
Epidermal Growth Factor
epigallocatechin gallate (EGCG)
ergothioneine
fibroblast growth factor
fisetin
flavonoids
flaxseed
fo-ti
fucoxanthin
Gac
Gerovital H3
ginkgo biloba
Ginsenosides
Glabridin
goji berry
green tea
greens blend (proprietary)
Haematococcus pluvialis
hazelnut
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
icariin
L-carnosine
lutein
Lycium
magnesium
Matcha
Melatonin
mixed carotenoids
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oolong tea
Peptides
Phytoene
Phytofluene
polypeptide complex (proprietary)
polyphenols
protein
pyrroloquinoline quinone
quercetin
resveratrol
Rhodiola
royal jelly
Salidroside
selenium
Shilajit
silicon
soy isoflavones
soybean
Squalene
Trans-pterostilbene
Tremella
Triterpenes
turmeric
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
Watermelon
Xanthophyll
Yerba mate
Zinc
β-nicotinamide mononucleotide (NMN)