Evidence supporting the use of: Vitamin E
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E is an antioxidant, and its use in aging prevention is primarily supported by scientific rationale, though the strength of the evidence is moderate to low. The interest in vitamin E for aging comes from its role as a fat-soluble antioxidant, capable of neutralizing free radicals that contribute to oxidative stress—a key factor implicated in the aging process and age-related diseases. Laboratory and animal studies have shown that vitamin E can protect cell membranes from oxidative damage, theoretically slowing cellular aging. However, human studies are less conclusive. Several large-scale clinical trials and meta-analyses have found that vitamin E supplementation does not significantly reduce the risk of age-related diseases such as cardiovascular disease, cancer, or cognitive decline in the general population. In some cases, high-dose vitamin E supplementation has even been linked to increased mortality.

Despite the lack of strong evidence for disease prevention or lifespan extension, vitamin E continues to be marketed and used as an "anti-aging" supplement due to its biochemical properties and early promising research. It is also commonly included in skincare products, where it may provide some benefit in protecting skin from oxidative damage caused by UV exposure. However, experts generally recommend obtaining vitamin E from a balanced diet rather than supplements, unless there is a specific deficiency. In summary, while there is a scientific rationale for vitamin E in aging prevention, robust clinical evidence for its effectiveness in humans is lacking.

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Other ingredients used for Aging (prevention)

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
Fo-Ti
Fucoxanthin
fibroblast growth factor
Ginsenosides
Gac
Gerovital H3
Glabridin