Evidence supporting the use of: Vitamin A (retinyl palmitate)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A, particularly in the form of retinyl palmitate, is widely used in dermatology and skincare for its anti-aging properties. There is substantial scientific evidence supporting its efficacy in preventing and treating signs of skin aging, such as fine lines, wrinkles, and uneven pigmentation. Retinyl palmitate is a storage form of vitamin A that is converted in the skin to retinol, and subsequently to retinoic acid—the biologically active form. Retinoic acid has been shown in multiple clinical studies to promote collagen production, increase epidermal thickness, and accelerate cellular turnover, all of which contribute to a more youthful skin appearance.

Topical application of vitamin A derivatives (retinoids) has been demonstrated to reduce photodamage, improve skin texture, and diminish hyperpigmentation. These effects are primarily due to modulation of gene expression in skin cells, leading to enhanced repair and regeneration. While retinyl palmitate is less potent than retinoic acid, it is better tolerated and still provides measurable benefits with regular use, making it a preferred ingredient in over-the-counter anti-aging products. Thus, the use of retinyl palmitate for the prevention and treatment of skin aging is supported by a strong body of scientific research, though it is generally less effective than prescription-strength retinoids.

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