Evidence supporting the use of: Vitamin A (retinyl not specified)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A, particularly in its active forms such as retinol and retinoic acid, has scientific support for its role in aging prevention, especially in dermatology. Topical retinoids are well-studied treatments for photoaging—skin aging caused by sun exposure. Retinoids influence cellular differentiation, stimulate collagen synthesis, and enhance skin turnover, which can reduce the appearance of fine lines, wrinkles, and hyperpigmentation. Multiple randomized controlled trials and meta-analyses have shown that topical retinoids improve skin texture and reduce clinical signs of aging. Oral vitamin A is essential for normal skin health, but its use for aging prevention is less substantiated and carries a risk of toxicity at high doses.

Despite this, the evidence primarily supports topical, rather than oral, application. Systemic vitamin A supplementation for aging prevention in healthy individuals is not broadly recommended and may be harmful in excess. The anti-aging effects are thus largely confined to dermatological improvements, and the evidence does not extend to systemic slowing of the aging process. The overall quality of evidence is moderate, supporting its use in skin aging, but not for general aging prevention. Hence, the evidence rating is 2.

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Products containing Vitamin A (retinyl not specified)

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