Evidence supporting the use of: Vitamin A (retinyl acetate)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A (retinyl acetate), particularly in the form of topical retinoids (such as retinol and tretinoin), has scientific backing for its use in the prevention and treatment of certain signs of skin aging. Research has shown that topical Vitamin A derivatives can stimulate collagen production, promote epidermal cell turnover, and improve skin texture and pigmentation. Multiple clinical studies have demonstrated that regular application of topical retinoids can reduce the appearance of fine wrinkles, mottled hyperpigmentation, and roughness—common features of photoaged skin. The mechanism involves modulation of gene expression in skin cells, resulting in enhanced repair and regeneration.

However, evidence for oral supplementation of Vitamin A (including retinyl acetate) for aging prevention in otherwise healthy adults is limited and not well supported by robust clinical trials. High doses of oral Vitamin A can be toxic and are not recommended for anti-aging purposes. The majority of scientific support centers on the topical application of Vitamin A derivatives. In summary, Vitamin A is scientifically validated for certain anti-aging effects when applied topically to the skin, but evidence is less clear or lacking for oral use in aging prevention.

More about Vitamin A (retinyl acetate)
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