Evidence supporting the use of: Vitamin A (retinol acetate)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A (retinol acetate) is primarily supported by scientific evidence for its role in skin health and aging prevention, particularly in topical formulations. Retinoids, derivatives of vitamin A, are well-documented to influence skin cell turnover, stimulate collagen production, and reduce the appearance of fine lines and wrinkles. Numerous clinical studies have demonstrated the efficacy of topical retinoic acid (tretinoin) and, to a lesser extent, retinol (a less potent precursor), in improving signs of photoaging such as roughness, hyperpigmentation, and wrinkles. The mechanism is thought to involve increased dermal collagen synthesis and normalization of epidermal differentiation.

Oral supplementation of vitamin A is less commonly recommended for aging prevention, as there is limited evidence that systemic intake slows skin aging in healthy, well-nourished individuals. Additionally, excessive oral vitamin A can be toxic and is not advisable for this purpose. Most scientific validation centers on topical use, where vitamin A derivatives are considered gold standard ingredients in dermatology for anti-aging.

In summary, scientific validation exists for the use of retinoids (including retinol acetate) in the prevention and treatment of skin aging, but this is specific to topical application. The evidence rating is moderate (3/5), reflecting strong support for topical use but not for oral supplementation or systemic anti-aging effects.

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Products containing Vitamin A (retinol acetate)

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