Evidence supporting the use of: Vitamin A (retinol)
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A (retinol) is scientifically validated for its role in the prevention and treatment of visible signs of skin aging, primarily through topical application. Retinoids, which include retinol and its derivatives, have been extensively studied in dermatology. Clinical trials have shown that topical retinoids can improve the appearance of fine lines, wrinkles, skin roughness, and mottled pigmentation associated with photoaging (aging caused by sun exposure). These effects are attributed to increased collagen production, stimulation of new blood vessel formation in the skin, and enhanced epidermal cell turnover.

The most robust evidence comes from randomized controlled trials using tretinoin (all-trans retinoic acid), a prescription-strength retinoid, but over-the-counter retinol has also demonstrated efficacy, albeit to a lesser degree. Studies have documented measurable improvements in skin texture and elasticity with consistent use. The American Academy of Dermatology and other expert bodies recognize retinoids as the gold standard topical treatment for aging skin. Oral vitamin A supplementation is not recommended for anti-aging due to potential toxicity and lack of evidence for skin benefits.

In summary, the use of topical vitamin A derivatives is strongly supported by scientific evidence for the prevention and treatment of skin aging, with a well-established mechanism of action and a significant body of clinical research.

More about Vitamin A (retinol)
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Products containing Vitamin A (retinol)

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