Evidence supporting the use of: Superoxide Dismutase
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide Dismutase (SOD) is an endogenous antioxidant enzyme that plays a crucial role in protecting cells from oxidative stress by catalyzing the dismutation of superoxide radicals into oxygen and hydrogen peroxide. The rationale for using SOD in aging prevention is based on the theory that oxidative damage contributes to the aging process and age-related diseases. Several laboratory and animal studies have demonstrated that increased SOD activity is associated with reduced oxidative damage and extended lifespan in some model organisms. However, evidence in humans is limited. Oral supplementation with SOD poses challenges, as the enzyme is largely degraded in the digestive tract, though some formulations attempt to improve bioavailability.

Clinical studies in humans are sparse and often small in scale. Some trials suggest that SOD supplementation may reduce markers of oxidative stress and inflammation, but robust evidence showing a direct impact on aging or age-related outcomes is lacking. Systematic reviews and meta-analyses conclude that while SOD’s role as an antioxidant is scientifically established, the effectiveness of SOD supplementation for aging prevention in humans remains unproven. Therefore, while there is a scientific basis for investigating SOD’s role in aging, current evidence supporting its use as an anti-aging supplement in humans is weak and insufficient for strong recommendations.

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