Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits and vegetables, and its use for aging prevention is primarily justified by scientific investigation, though the supporting evidence is still preliminary. Laboratory studies and animal models have shown that quercetin possesses antioxidant, anti-inflammatory, and senolytic properties—that is, the ability to selectively clear senescent (aging) cells, which accumulate with age and contribute to tissue dysfunction and chronic inflammation. Notably, a 2018 study published in Nature Medicine demonstrated that quercetin, especially when combined with the drug dasatinib, could reduce senescent cell burden and improve healthspan in aged mice. Early phase human trials, such as a 2019 pilot study in EBioMedicine, indicate that quercetin-dasatinib therapy can reduce markers of cellular senescence in humans, though the sample sizes are small and long-term outcomes are not established.

Despite these promising findings, robust clinical evidence in humans is lacking. Most human studies to date are preliminary, with limited participant numbers and short durations. There are no large-scale randomized controlled trials that definitively prove quercetin’s effectiveness in slowing human aging or extending lifespan. Thus, while the mechanistic rationale is strong and preclinical data are encouraging, the overall evidence rating is moderate (2/5) and further research is needed before quercetin can be recommended as a validated anti-aging intervention.

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