Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyrroloquinoline Quinone (PQQ) is a redox cofactor and antioxidant that has garnered interest for its potential role in aging and longevity. Scientific interest in PQQ stems from its capacity to reduce oxidative stress, promote mitochondrial biogenesis, and modulate cellular signaling pathways involved in aging. Several animal studies have demonstrated that PQQ supplementation can enhance mitochondrial function, protect against cognitive decline, and improve markers of oxidative damage. For example, research in rodents has shown that PQQ can upregulate genes related to mitochondrial proliferation and reduce biomarkers of lipid peroxidation.

However, human clinical evidence is limited. Some small-scale trials have reported improvements in markers of oxidative stress and inflammation, and one study found modest cognitive benefits in middle-aged and elderly adults. Despite these findings, no large, long-term clinical trials have conclusively demonstrated that PQQ supplementation can prevent or slow aging in humans. Thus, while PQQ's biological effects are promising in preclinical models, the clinical evidence supporting its use for aging prevention is currently weak to moderate at best. More robust, long-term studies in humans are needed to clarify its efficacy and safety profile for this indication.

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