Evidence supporting the use of: Polyphenols
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols, a diverse group of naturally occurring compounds found in plants (including flavonoids, phenolic acids, stilbenes, and lignans), have garnered significant scientific interest for their potential anti-aging effects. Multiple in vitro, animal, and some human studies suggest that polyphenols possess antioxidant, anti-inflammatory, and cellular protective properties. These properties can help mitigate cellular damage caused by oxidative stress, a key factor implicated in aging and age-related diseases.

Some of the most extensively studied polyphenols include resveratrol (found in grapes and red wine), catechins (in green tea), and curcumin (in turmeric). Research has shown these compounds can activate pathways such as SIRT1 and AMPK, which are associated with improved cellular health, DNA repair, and extended lifespan in model organisms. For example, resveratrol has demonstrated lifespan extension in yeast, worms, and mice, though translation of these effects to humans remains less clear.

Clinical evidence in humans is more limited and sometimes inconsistent. While some studies show improvements in biomarkers of aging (such as reduced inflammation, improved endothelial function, and increased antioxidant capacity), there is currently no conclusive evidence that polyphenol supplementation significantly extends human lifespan or prevents all aspects of aging. However, regular consumption of polyphenol-rich foods is associated with reduced risk of chronic diseases (cardiovascular disease, neurodegenerative disorders), which are closely linked with aging.

In summary, the use of polyphenols for aging prevention is supported by mechanistic and preclinical scientific data, with moderate evidence from human studies, meriting a mid-level rating.

More about polyphenols
More about Aging (prevention)

Other ingredients used for Aging (prevention)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7-hydroxymatairesinol (HMR)
7-Keto-DHEA
8-Prenylnaringenin
Abalone
Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
Algae
algal oil
Algal protein
Allantoin
Almond fruit
Alpha hydroxy acids
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anemarrhena asphodeloides
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
Antrodia camphorata
apigenin
apple
apricot
argan nut oil
Aronia melanocarpa
ascorbyl palmitate
ashitaba
ashwagandha
astaxanthin
astragaloside
astragalus
avocado
beta-carotene
bioflavonoids
bird\'s nest
Brassica
Brussel sprouts
Carnosine
carotene (unspecified)
carrot
catalase
cauliflower
Chinese Ligustrum berry
cistanche
coenzyme Q10 (CoQ10)
collagen
cruciferous
cryptoxanthin
curcumin
Curcuminoid
cycloastragenol
DHEA
DHEA (dehydroepiandrosterone)
dismutase
dodder
Dunaliella
Dunaliella salina
ellagic acid
epicatechin
Epidermal Growth Factor
epigallocatechin gallate (EGCG)
ergothioneine
fibroblast growth factor
fisetin
flavonoids
flaxseed
fo-ti
fucoxanthin
Gac
Gerovital H3
ginkgo biloba
Ginsenosides
Glabridin
goji berry
green tea
greens blend (proprietary)
Haematococcus pluvialis
hazelnut
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
icariin
L-carnosine
lutein
Lycium
magnesium
Matcha
Melatonin
mixed carotenoids
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oolong tea
Peptides
Phytoene
Phytofluene
polypeptide complex (proprietary)
polyphenols
protein
pyrroloquinoline quinone
quercetin
resveratrol
Rhodiola
royal jelly
Salidroside
selenium
Shilajit
silicon
soy isoflavones
soybean
Squalene
Trans-pterostilbene
Tremella
Triterpenes
turmeric
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
Watermelon
Xanthophyll
Yerba mate
Zinc
β-nicotinamide mononucleotide (NMN)