Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyamines, such as spermidine and spermine, are naturally occurring compounds found in all living cells and have been studied for their potential role in aging and longevity. The scientific interest in polyamines and aging stems from their involvement in cellular processes like DNA stabilization, autophagy regulation, cell growth, and proliferation. Several animal studies have shown that dietary supplementation with spermidine can extend lifespan in model organisms such as yeast, worms, flies, and mice, primarily by enhancing autophagy, a cellular housekeeping process that declines with age.

In humans, observational studies have found correlations between higher dietary polyamine (especially spermidine) intake and reduced risk of cardiovascular disease and all-cause mortality. For example, an epidemiological study published in Nature Medicine (2018) linked higher spermidine consumption with lower blood pressure and improved survival in humans. However, direct clinical trials in humans are limited, and most evidence is still preclinical or observational. There is growing interest in spermidine-rich supplements and foods (like wheat germ, soy, and some cheeses) for healthy aging, but more rigorous research is needed to confirm efficacy and determine optimal dosing and safety.

Overall, while there is promising scientific data suggesting a role for polyamines in the prevention of aging-related decline, the evidence is not yet definitive, and more human studies are required before widespread clinical recommendations can be made.

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