Peptides, short chains of amino acids, have been increasingly studied for their potential role in aging prevention and skin health. Scientific evidence supports that certain peptides, particularly those used in topical formulations (such as matrixyl or copper peptides), can stimulate collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. Clinical trials and in vitro studies have shown improvements in skin texture and hydration, likely due to the ability of these peptides to signal skin cells to perform regenerative functions or inhibit the breakdown of collagen and elastin. Additionally, some oral peptide supplements are being investigated for their anti-aging properties, such as promoting muscle mass, skin health, and metabolic function, although robust clinical evidence in humans is still limited for oral applications.

While peptides are not a panacea for aging, and the degree of benefit can vary depending on peptide type and delivery method, the use of specific peptides in dermatology is supported by moderate scientific evidence. The rating of 3 reflects that, although there is credible research and some clinical validation, larger and more long-term human studies are needed to fully establish efficacy, optimal dosing, and safety, especially for systemic or oral use. In summary, peptides have a scientifically supported role, particularly in topical anti-aging skin care, although the strength of evidence is moderate rather than definitive.