Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ostarine (also known as MK-2866 or Enobosarm) is a selective androgen receptor modulator (SARM) that has been investigated primarily for its ability to increase lean muscle mass and improve physical function, particularly in populations affected by muscle wasting such as the elderly or those with chronic illnesses. The rationale for its use in aging (prevention or mitigation) is largely based on its anabolic effects, which may counteract sarcopenia—the age-related loss of muscle mass and strength that contributes to frailty and decreased quality of life. Several clinical trials have demonstrated that Ostarine can increase lean body mass and, to a lesser extent, improve physical function in older adults or cancer patients experiencing muscle wasting. However, these studies are relatively small, short-term, and often not focused specifically on otherwise healthy aging adults. There is limited long-term safety data, and Ostarine is not approved by the FDA for anti-aging or muscle preservation in the elderly outside of clinical trials. While the mechanistic rationale is sound and there is some early clinical evidence, it is not robust enough to justify widespread use for aging prevention. Potential side effects and regulatory concerns (it is a banned substance in sports and not approved for general use) further limit its application. Therefore, scientific evidence exists but is modest, incomplete, and not definitive for aging prevention in the general population.

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