Evidence supporting the use of: Lutein
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Lutein is a carotenoid antioxidant commonly found in green leafy vegetables and is widely studied for its role in eye health and age-related conditions. While lutein is not a generalized anti-aging supplement for all aspects of aging, it has been scientifically validated for its role in supporting vision and potentially delaying age-related macular degeneration (AMD), a major cause of vision loss in older adults. Several observational studies and randomized controlled trials (RCTs) have shown that higher dietary intake or supplementation of lutein is associated with increased macular pigment density and reduced risk or progression of AMD. The Age-Related Eye Disease Study 2 (AREDS2), a large multicenter trial, found that supplementation with lutein and zeaxanthin was beneficial in reducing the progression of advanced AMD compared to placebo.
However, evidence for lutein’s role in broader aging processes—such as cognitive decline, skin aging, or overall lifespan extension—is limited and less robust. Some preliminary studies suggest potential neuroprotective and skin health benefits due to lutein’s antioxidant properties, but these findings are not yet conclusive or widely replicated. Overall, lutein’s use in aging prevention is scientifically justified mainly for age-related visual conditions, with moderate-quality evidence (hence a rating of 2) for those effects, and much weaker support for other aspects of aging.
Other ingredients used for Aging (prevention)
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid7-hydroxymatairesinol (HMR)
7-Keto-DHEA
8-Prenylnaringenin
Abalone
Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
Algae
algal oil
Algal protein
Allantoin
Almond fruit
Alpha hydroxy acids
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anemarrhena asphodeloides
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
Antrodia camphorata
apigenin
apple
apricot
argan nut oil
Aronia melanocarpa
ascorbyl palmitate
ashitaba
ashwagandha
astaxanthin
astragaloside
astragalus
avocado
beta-carotene
bioflavonoids
bird\'s nest
Brassica
Brussel sprouts
Carnosine
carotene (unspecified)
carrot
catalase
cauliflower
Chinese Ligustrum berry
cistanche
coenzyme Q10 (CoQ10)
collagen
cruciferous
cryptoxanthin
curcumin
Curcuminoid
cycloastragenol
DHEA
DHEA (dehydroepiandrosterone)
dismutase
dodder
Dunaliella
Dunaliella salina
ellagic acid
epicatechin
Epidermal Growth Factor
epigallocatechin gallate (EGCG)
ergothioneine
fibroblast growth factor
fisetin
flavonoids
flaxseed
fo-ti
fucoxanthin
Gac
Gerovital H3
ginkgo biloba
Ginsenosides
Glabridin
goji berry
green tea
greens blend (proprietary)
Haematococcus pluvialis
hazelnut
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
icariin
L-carnosine
lutein
Lycium
magnesium
Matcha
Melatonin
mixed carotenoids
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oolong tea
Peptides
Phytoene
Phytofluene
polypeptide complex (proprietary)
polyphenols
protein
pyrroloquinoline quinone
quercetin
resveratrol
Rhodiola
royal jelly
Salidroside
selenium
Shilajit
silicon
soy isoflavones
soybean
Squalene
Trans-pterostilbene
Tremella
Triterpenes
turmeric
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
Watermelon
Xanthophyll
Yerba mate
Zinc
β-nicotinamide mononucleotide (NMN)
Products containing lutein
Nature's Sunshine Estro-Assured (Formerly Breast Assured)
Nature's Sunshine Lutein
Nature's Sunshine Marine Glo Collagen
Nature's Sunshine Perfect Eyes
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine VitaWave
