Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-Glutathione is a tripeptide composed of glutamine, cysteine, and glycine, and is recognized as a key intracellular antioxidant. Its proposed use in aging prevention is primarily based on its biological role in neutralizing reactive oxygen species (ROS) and maintaining redox balance within cells. As oxidative stress is implicated in cellular aging and the development of age-related diseases, the rationale for glutathione supplementation is to enhance the body's natural defense mechanisms.

Scientific evidence in humans, however, remains limited and mixed. Some small clinical studies have shown that oral or intravenous glutathione can increase blood glutathione levels and may improve certain biomarkers of oxidative stress. For example, a 2015 pilot study found that oral glutathione supplementation raised body stores and markers of antioxidant capacity in healthy adults. Animal studies have suggested potential anti-aging effects, such as improved mitochondrial function and reduced age-related oxidative damage.

Despite these findings, robust clinical trials demonstrating clear anti-aging benefits in human populations are lacking. There is insufficient evidence to confirm long-term efficacy for aging prevention, and oral bioavailability of glutathione is debated. Most expert reviews conclude that while glutathione is essential for cellular health and aging processes, supplementation for aging prevention requires further research. Therefore, its use is scientifically motivated but not yet strongly validated.

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