Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydroxymethylbutyrate (HMB) has some scientific evidence supporting its use in the context of aging, particularly for the prevention of age-related muscle loss (sarcopenia). HMB is a metabolite of the amino acid leucine and is thought to reduce muscle protein breakdown, which is a key factor in the muscle loss associated with aging. Several randomized controlled trials and meta-analyses have found that HMB supplementation, especially when combined with resistance exercise, can help older adults maintain or increase lean muscle mass and improve muscle strength. However, the effects are generally modest, and not all studies have shown significant benefits. The mechanism is believed to involve HMB’s ability to modulate protein synthesis and reduce muscle proteolysis. While HMB is sometimes marketed as an "anti-aging" supplement, its primary studied benefit in older populations is the maintenance of muscle mass rather than broad anti-aging effects. There is limited evidence for other aging-related outcomes such as cognitive function or longevity. Overall, HMB is supported by scientific studies for muscle preservation in aging, but the evidence is not strong enough to warrant a higher rating, and it should not be considered a comprehensive anti-aging intervention.

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