Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Growth factors are proteins that regulate cell growth, proliferation, and differentiation. Their use in anti-aging therapies, particularly in dermatology and skin care, is supported by some scientific evidence but remains an area of ongoing research. Topical formulations containing growth factors, such as epidermal growth factor (EGF), transforming growth factor-beta (TGF-β), and fibroblast growth factors, have been shown in some clinical studies to improve skin texture, reduce fine lines, and promote wound healing by stimulating collagen and elastin synthesis.

However, most of the evidence comes from small-scale studies, in vitro experiments, or animal models. Human clinical trials suggest modest improvements in skin appearance and reduction in signs of aging, but often have limitations such as small sample sizes, short durations, or lack of blinding. The mechanism by which exogenously applied growth factors penetrate the skin and exert their effects is also not fully understood, and the long-term safety of such treatments is not well established.

Currently, growth factors are not approved as systemic anti-aging therapies but are used in certain cosmetic and dermatologic products, often marketed for skin rejuvenation. While there is scientific rationale and preliminary evidence supporting their use for aging prevention in the skin, robust, large-scale clinical trials are lacking. Thus, while there is scientific interest and some validation, the overall quality and quantity of evidence at present is moderate to low.

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