Gac (Momordica cochinchinensis) is a fruit native to Southeast Asia, traditionally valued for its vibrant orange-red pulp, which is rich in carotenoids such as beta-carotene and lycopene. Scientific interest in Gac as an anti-aging agent primarily centers on its high antioxidant content. Oxidative stress caused by free radicals is a major contributor to cellular aging, and antioxidants are thought to mitigate these effects by neutralizing free radicals.

Several laboratory studies have measured the antioxidant activity of Gac fruit extracts, noting their potential to reduce oxidative damage in vitro. For example, research has shown that Gac oil contains higher concentrations of beta-carotene and lycopene than many other fruits and vegetables, both of which are associated with skin health and the prevention of photoaging. However, clinical studies in humans directly linking Gac consumption to slowed aging or improved markers of aging are lacking. Most evidence remains preclinical (lab-based or animal models), with limited translation to human outcomes.

In summary, while Gac is traditionally consumed for general health and its antioxidant-rich profile is scientifically established, robust clinical data supporting its use specifically for aging prevention are currently insufficient. Its use as an anti-aging supplement is therefore based on plausible mechanisms and promising preliminary data, but not on strong human clinical evidence.