Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fibroblast growth factor (FGF) is a family of proteins involved in cell growth, tissue repair, and development. In the context of aging and its prevention, FGF—particularly FGF-2 and FGF-21—has been investigated in preclinical (animal and cellular) studies for its potential to support tissue regeneration, improve metabolic health, and modulate pathways implicated in aging, such as cellular senescence and oxidative stress. Some studies suggest that FGF-21, for example, can improve metabolic parameters and extend lifespan in mice. Similarly, FGF-2 has been shown to stimulate skin fibroblast proliferation and aid in wound healing, which has led to its inclusion in some anti-aging skin products.

However, robust clinical evidence in humans is limited. Most of the supportive data come from laboratory and animal research, with only preliminary or small-scale studies in humans. There is currently no large-scale clinical trial demonstrating that FGF administration can broadly prevent or reverse aging in humans. The main rationale for its use in anti-aging therapies is based on its biological role in tissue maintenance and regeneration, rather than direct evidence of anti-aging effects in people. Thus, while there is a scientific rationale and some early supportive evidence, the overall strength of evidence for FGF in aging prevention is modest at best.

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