Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ergothioneine is an amino acid antioxidant found in mushrooms and some other foods. Its use in the context of aging prevention is justified primarily by scientific interest rather than traditional use, as there is limited historical evidence of it being used for this purpose. The rationale for its use centers on its role as a potent antioxidant and cytoprotective agent. Laboratory and animal research indicates that ergothioneine is efficiently transported into cells via a specific transporter (OCTN1), accumulates in tissues susceptible to oxidative stress, and can protect cells from oxidative damage, a process implicated in aging and age-related diseases.

Several preclinical studies have demonstrated that ergothioneine can reduce oxidative stress markers and inflammation in various models, and low blood levels of ergothioneine have been associated with increased risk of cognitive decline and frailty in older adults. However, there is currently a lack of large, well-controlled human clinical trials directly showing that ergothioneine supplementation slows aging or extends lifespan. Thus, while the mechanistic rationale and some epidemiological associations are promising, direct evidence in humans remains insufficient. As of 2024, the scientific community considers ergothioneine a promising but unproven candidate for aging prevention, and more research is needed to establish its efficacy.

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